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Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders Review

Wanqiang Wu, Qingmin Kong, Peijun Tian, Qixiao Zhai, Gang Wang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Yuan Kun Lee, Wei Chen

Engineering 2020, Volume 6, Issue 4,   Pages 415-423 doi: 10.1016/j.eng.2019.07.026

Abstract: the gut microbiota and the brain via the gut–brain axis, and on the onset and development of neurologicaldisorders triggered by gut microbiota dysbiosis.relative infancy, clarifying the molecular mechanism that underlies how the gut microbiota regulates neurologicalfunctions not only holds the promise of revealing potentially novel pathogeneses of neurological disordersdisorders.

Keywords： Gut microbiota     Gut–brain axis     Neurological disorders     Intervention strategies    

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Efficacy of intelligent diagnosis with a dynamic uncertain causality graph model for rare disorders of

Dongping Ning, Zhan Zhang, Kun Qiu, Lin Lu, Qin Zhang, Yan Zhu, Renzhi Wang

Frontiers of Medicine 2020, Volume 14, Issue 4,   Pages 498-505 doi: 10.1007/s11684-020-0791-8

Abstract: Disorders of sex development (DSD) are a group of rare complex clinical syndromes with multiple etiologies

Keywords： disorders of sex development (DSD)     intelligent diagnosis     dynamic uncertain causality graph    

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The development and benefits of metformin in various diseases

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 388-431 doi: 10.1007/s11684-023-0998-6

Abstract: types of diseases, including metabolic associated diseases, cancer, aging and age-related diseases, neurologicaldisorders.

Keywords： metformin     metabolism     cancer     aging     neurological disorder    

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Therapeutic effects of thalidomide in hematologic disorders: a review

Miao Xu, Yu Hou, Lei Sheng, Jun Peng

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 290-300 doi: 10.1007/s11684-013-0277-z

Abstract: With appropriate safeguards, thalidomide may benefit patients suffering from a broad variety of disorders

Keywords： thalidomide     multiple myeloma     lymphoma    

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Mesenchymal stem cells and immune disorders: from basic science to clinical transition

Shihua Wang, Rongjia Zhu, Hongling Li, Jing Li, Qin Han, Robert Chunhua Zhao

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 138-151 doi: 10.1007/s11684-018-0627-y

Abstract: immunity in an autologous/allergenic manner makes them an attractive therapeutic cell type for immune disorders

Keywords： mesenchymal stem cell     clinical transition     immune disorders    

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Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function

Frontiers of Medicine doi: 10.1007/s11684-023-1006-x

Abstract: Highly clinical and genetic heterogeneity of neurodevelopmental disorders presents a major challenge

Keywords： neurodevelopmental disorder     autosomal recessive intellectual disability     consanguinity     spastic paraplegia     hearing loss     TMEM141    

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Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral

Haiyan LU, Yongting WANG, Falei YUAN, Jianrong LIU, Lili ZENG, Guo-Yuan YANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 86-93 doi: 10.1007/s11684-011-0118-x

Abstract: ischemic brain and that NT-1 gene transfer might present a valuable approach to treat brain ischemic disorders

Keywords： adeno-associated virus     angiogenesis     gene transfer     ischemia     middle cerebral artery occlusion     netrin-1    

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Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders

Yuqiu Han, Xiangyang Jiang, Qi Ling, Li Wu, Pin Wu, Ruiqi Tang, Xiaowei Xu, Meifang Yang, Lijiang Zhang, Weiwei Zhu, Baohong Wang, Lanjuan Li

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 471-481 doi: 10.1007/s11684-019-0686-8

Abstract: the interaction between immunosuppressants and ABX alters the IM and thus leads to glucose metabolism disordersmicrobial functional profiles showed significant correlation with hepatic lipid accumulation and glucose disordersmicrobiome and its metabolic capacities, which might contribute to hepatic lipid accumulation and glucose disorders

Keywords： antibiotics     tacrolimus     glucose disorders     microbiome    

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Abnormal glycosylated hemoglobin as a predictive factor for glucose metabolism disorders in antipsychotic

XU Leping, JI Juying, DUAN Yiyang, SHI Hui, ZHANG Bin, SHAO Yaqin, SUN Jian

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 316-319 doi: 10.1007/s11684-007-0061-z

Abstract: influencing factors, as well as to discuss the relationship between the occurrence of glucose metabolism disordersPatients with abnormal HbAc are more likely to have a higher risk of having glucose metabolism disorders

Keywords： significant difference     occurrence     hemoglobin     risperidone treatment     abnormal    

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A Brief Review of Artificial Intelligence Applications and Algorithms for Psychiatric Disorders Review

Guang-Di Liu, Yu-Chen Li, Wei Zhang, Le Zhang

Engineering 2020, Volume 6, Issue 4,   Pages 462-467 doi: 10.1016/j.eng.2019.06.008

Abstract: research projects have recently been carried out to study the etiology and mechanisms of psychiatric disordersAlthough psychiatric disorders are part of the brain sciences, psychiatrists still diagnose them basedreason, this study briefly reviews three main brain observation techniques used to study psychiatric disorders

Keywords： Artificial intelligence     Psychiatric disorders     Neuroimaging    

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Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from

Zhengqian Li, Taotao Liu, Ning Yang, Dengyang Han, Xinning Mi, Yue Li, Kaixi Liu, Alain Vuylsteke, Hongbing Xiang, Xiangyang Guo

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 533-541 doi: 10.1007/s11684-020-0786-5

Abstract: In addition to major respiratory distress, characteristic neurological manifestations are also described

Keywords： coronavirus disease 2019 (COVID-19)     SARS-CoV-2     neurological manifestations     neuroinvasion     brain    

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Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and Prospects Review

Tingting Peng, Yangyan Chen, Wanshan Hu, Yao Huang, Minmin Zhang, Chao Lu, Xin Pan, Chuanbin Wu

Engineering 2023, Volume 30, Issue 11,   Pages 170-189 doi: 10.1016/j.eng.2023.05.009

Abstract:

Microneedles (MNs) can be used for the topical treatment of skin disorders as they directly delivermolecules, macromolecules, nanomedicines, living cells, bacteria, and exosomes) for treating various skin disorderssummarized the various applications, emerging challenges, and developmental prospects of MNs in skin disorders

Keywords： Microneedles     Transdermal drug delivery system     Skin disorders     Treatments     Challenges     Prospects    

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Physiological functions and clinical implications of the N-end rule pathway

Yujiao Liu,Chao Liu,Wen Dong,Wei Li

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 258-270 doi: 10.1007/s11684-016-0458-7

Abstract:

The N-end rule pathway is a unique branch of the ubiquitin-proteasome system in which the determination of a protein’s half-life is dependent on its N-terminal residue. The N-terminal residue serves as the degradation signal of a protein and thus called N-degron. N-degron can be recognized and modifed by several steps of post-translational modifications, such as oxidation, deamination, arginylation or acetylation, it then polyubiquitinated by the N-recognin for degradation. The molecular basis of the N-end rule pathway has been elucidated and its physiological functions have been revealed in the past 30 years. This pathway is involved in several biological aspects, including transcription, differentiation, chromosomal segregation, genome stability, apoptosis, mitochondrial quality control, cardiovascular development, neurogenesis, carcinogenesis, and spermatogenesis. Disturbance of this pathway often causes the failure of these processes, resulting in some human diseases. This review summarized the physiological functions of the N-end rule pathway, introduced the related biological processes and diseases, with an emphasis on the inner link between this pathway and certain symptoms.

Keywords： N-end rule pathway     Ate1     cardiovascular development     neurogenesis     spermatogenesis     neurodegenerative disorders    

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Bioactive Components of Chinese Herbal Medicines in the Treatment of Glucose and Lipid Metabolism Disorders Review

Ying Zhang, Jiaming Ju, Lei Jiao, Baofeng Yang

Engineering 2023, Volume 29, Issue 10,   Pages 73-82 doi: 10.1016/j.eng.2023.03.004

Abstract:

Disturbed cholesterol and glucose homeostasis play crucial roles in the development of various diseases such as cardiovascular diseases, cerebrovascular diseases, central nervous system diseases, and cancer. An increasing number of studies have shown that excessive body fat accumulation is associated with type 2 diabetes or insulin resistance in a vicious cycle. This vicious cycle promotes the occurrence and development of the aforementioned diseases. Therefore, stabilizing the blood lipids and blood glucose of patients is the predominant strategy for improving the symptoms of patients with cardiovascular, cerebrovascular, and central nervous system diseases. Traditional Chinese medicine, mainly Chinese herbal medicine (CHM), has a history of more than 2000 years in China, which has established a unique theory and accumulated a great wealth of clinical experience. Moreover, CHM has been widely used in China and other countries for the treatment of cardiovascular and cerebrovascular diseases, with the advantages of preventing and curing hyperlipidemia, diabetes, hypertension, and other diseases. However, the use of CHM in Western countries remains rather limited, partly because of the incomplete understanding of multiple complex components and uncertain pharmacological mechanisms. Herein, we review and discuss the benefits, molecular mechanisms, and clinical research progress of bioactive components of CHM and their preparations as therapeutics for hyperlipidemia and hyperglycemia.

Keywords： Chinese herbal medicines     Hyperlipidemia     Hyperglycemia     Cardiovascular and cerebrovascular diseases    

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Metabonomic study of the biochemical profiles of heterozygous myostatin knockout swine

Jianxiang XU,Dengke PAN,Jie ZHAO,Jianwu WANG,Xiaohong HE,Yuehui MA,Ning LI

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 90-99 doi: 10.15302/J-FASE-2015045

Abstract: Myostatin gene ( ) knockout (KO) mice show possible effects for the prevention or treatment of metabolic disorders

Keywords： myostatin     transforming growth factor-β family     skeletal muscle     metabolic disorders     chromatography     mass    

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Title Author Date Type Operation

Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders

Wanqiang Wu, Qingmin Kong, Peijun Tian, Qixiao Zhai, Gang Wang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Yuan Kun Lee, Wei Chen

Journal Article

Efficacy of intelligent diagnosis with a dynamic uncertain causality graph model for rare disorders of

Dongping Ning, Zhan Zhang, Kun Qiu, Lin Lu, Qin Zhang, Yan Zhu, Renzhi Wang

Journal Article

The development and benefits of metformin in various diseases

Journal Article

Therapeutic effects of thalidomide in hematologic disorders: a review

Miao Xu, Yu Hou, Lei Sheng, Jun Peng

Journal Article

Mesenchymal stem cells and immune disorders: from basic science to clinical transition

Shihua Wang, Rongjia Zhu, Hongling Li, Jing Li, Qin Han, Robert Chunhua Zhao

Journal Article

Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function

Journal Article

Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral

Haiyan LU, Yongting WANG, Falei YUAN, Jianrong LIU, Lili ZENG, Guo-Yuan YANG

Journal Article

Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders

Yuqiu Han, Xiangyang Jiang, Qi Ling, Li Wu, Pin Wu, Ruiqi Tang, Xiaowei Xu, Meifang Yang, Lijiang Zhang, Weiwei Zhu, Baohong Wang, Lanjuan Li

Journal Article

Abnormal glycosylated hemoglobin as a predictive factor for glucose metabolism disorders in antipsychotic

XU Leping, JI Juying, DUAN Yiyang, SHI Hui, ZHANG Bin, SHAO Yaqin, SUN Jian

Journal Article

A Brief Review of Artificial Intelligence Applications and Algorithms for Psychiatric Disorders

Guang-Di Liu, Yu-Chen Li, Wei Zhang, Le Zhang

Journal Article

Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from

Zhengqian Li, Taotao Liu, Ning Yang, Dengyang Han, Xinning Mi, Yue Li, Kaixi Liu, Alain Vuylsteke, Hongbing Xiang, Xiangyang Guo

Journal Article

Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and Prospects

Tingting Peng, Yangyan Chen, Wanshan Hu, Yao Huang, Minmin Zhang, Chao Lu, Xin Pan, Chuanbin Wu

Journal Article

Physiological functions and clinical implications of the N-end rule pathway

Yujiao Liu,Chao Liu,Wen Dong,Wei Li

Journal Article

Bioactive Components of Chinese Herbal Medicines in the Treatment of Glucose and Lipid Metabolism Disorders

Ying Zhang, Jiaming Ju, Lei Jiao, Baofeng Yang

Journal Article

Metabonomic study of the biochemical profiles of heterozygous myostatin knockout swine

Jianxiang XU,Dengke PAN,Jie ZHAO,Jianwu WANG,Xiaohong HE,Yuehui MA,Ning LI

Journal Article